Par4 peptides and polypeptides

Details Par4 peptides and polypeptides Par4 peptides and polypeptides

C - Chemistry, Metallurgy

07

K

C07K 7/06 (2006.01) A61K 38/08 (2006.01) C07K 14/705 (2006.01)

Patent

CA 2399566

Members of the protease-activated receptor (PAR) family mediate cellular signaling in response to proteases. These receptors are characterized by a tethered peptide ligand at the extracellular amino terminus that is generated by minor proteolysis. Structure-activity analysis revealed that peptides and polypeptides can be designed to activate human PAR4.

Des membres de la famille du récepteur activé par protéase (PAR) induisent une signalisation cellulaire dans la réponse à des protéases. Ces récepteurs sont caractérisés par un ligand peptidique attaché au niveau de la terminaison amino-extracellulaire généré par une protéolyse mineure. Une analyse de structure-activité a révélé que des peptides et des polypeptides peuvent être conçus pour activer le PAR4 humain.

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