C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/115 (2006.01) A61K 39/155 (2006.01) A61K 39/295 (2006.01) C07K 14/135 (2006.01) C07K 16/10 (2006.01) C12N 7/04 (2006.01) C12N 9/24 (2006.01) G01N 33/569 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2232515
The hemagglutinin-neuraminidase (HN) and fusion (F) glycoproteins are coisolated and copurified from the parainfluenza virus type 1 (PIV-1) and parainfluenza virus type 3 (PIV-3). The HN and F glycoprotein are separately isolated and purified from parainfluenza virus type 2 (PIV-2). The glycoproteins formulated as vaccines, are highly immunogenic and protect relevant animal models against parainfluenza challenge. A vaccine containing the HN and F glycoproteins from PIV-3 was safe and immunogenic in adults and children. A trivalent vaccine containing HN and F glycoproteins from PIV-1, PIV-2 and PIV-3 generated an immune response capable of neutralizing each of the viruses.
Les glycoprotéines d'hémagglutinine-neuraminidase (HN) et de fusion (F) sont co-isolées et co-purifiées à partir du virus de para-influenza type 1 (PIV-1) et type 3 (PIV-3). Les glycoprotéines préparées sous forme de vaccins sont fortement immunogènes et protègent les modèles animaux visés contre l'agression du para-influenza. Un vaccin contenant les glycoprotéines HN et F de PIC-3 s'est avéré sûr et immunogène chez l'adulte et l'enfant. Un vaccin trivalent contenant des glycoprotéines HN et F provenant de PIV-1, PIV-2 et PIV-3 a produit une réponse immunitaire susceptible de neutraliser chacun des virus.
Cates George A.
Ewasyshyn Mary E.
Fahim Raafat E. F.
Jackson Gail E. D.
Klein Michel H.
Connaught Laboratories Limited
Sanofi Pasteur Limited/sanofi Pasteur Limitee
Yacoob Reza K.
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