Parallel fixed bed reactor and fluid contacting apparatus...

B - Operations – Transporting – 01 – L

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B01L 3/02 (2006.01) B01J 19/00 (2006.01) B01L 3/00 (2006.01) G01N 31/10 (2006.01)

Patent

CA 2297725

The present invention discloses an apparatus and method for rapid analysis of members of a combinatorial library. The apparatus includes a plurality of vessels for containing individual library members and a fluid handling system that apportions a test fluid about equally between each of the vessels. This allows for simultaneous screening of library members by detecting changes in test fluid following contact with individual library members. Fluid flow through each of the vessels is controlled using passive flow restrictors or active flow controllers to ensure that each library member contacts approximately the same amount of test fluid per unit time. The disclosed apparatus is especially useful for screening library members based on their ability to catalyze the conversion of fluid reactants.

L'invention porte sur un appareil et un procédé d'analyse rapide d'éléments d'une bibliothèque combinatoire. L'appareil comprend une pluralité de réceptacles destinés à contenir des éléments individuels de bibliothèque et un système de traitement de fluide qui répartit un fluide de test de manière approximativement égale entre chacun des réceptacles. Ceci permet de cribler simultanément des éléments de bibliothèque en détectant des modifications dans le fluide de test après que celui-ci ait été mis en contact avec des éléments individuels de bibliothèque. L'écoulement du fluide dans chaque réceptacle est régulé au moyen de limiteurs de débit passifs ou de régulateurs de débit actifs afin de permettre que chaque élément de bibliothèque vienne en contact approximativement avec la même quantité de fluide de test par unité de temps. L'appareil de cette invention est notamment utile pour cribler des éléments de bibliothèque en fonction de leur capacité à catalyser la conversion des réactifs du fluide.

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