C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
260/426, 260/247
C07F 13/00 (2006.01) C07F 5/00 (2006.01) C07C 101/26 (1985.01)
Patent
CA 1240679
ABSTRACT OF THE DISCLOSURE Paramagnetic, physiologically compatible paramag- netic complex salts from aminopolycarboxylic acids having the formulae I to IV Image (I) N-hydroxy-ethyl-N,N',N'-ethylene-diamine triacetic (HEDTA), Image (II) N,N,N',N",N"-diethylene-tirami.ne pentaace-tic (DTPA), HOH2C-CH2N(CH2COOH)Z (III) N-hydroxy-ethyl-imino diacetic acid, Image (IV) wherein m represents the numbers 1 to 4, n repesents the numbers 0 to 2, R' represents a saturated or unsaturated hydrocarbon radical containing 4 to 12 hydrocarbon atoms or the group -CH2-COOH, or diphosphonic acids having the general formula V Image (V) wherein R2 represents hydrogen, alkyl containing 1 to 4 carbon atoms, halogen, the hydroxy, amino or CH2-COOH group and R3 represents hydrogen, alkyl containing 1 to 4 carbon atoms, the -CH2-COOH group or also halogen when R2 represents halogen, and from the ions of the lanthanide elements having the atomic numbers 57 to 70 or from the ions of the transi- tion metals having the atomic numbers 21 to 29, 42 and 44 and from an organic base, glucamine, N-methyl glucamine, N,N-dimethyl glucamine, ethanol amine, diethanol amine, morpholine, lysine, ornithine and arginine being suitable as the organic base useful in influencing the relaxation times in NMR-diagnostics, also methods for their prepara- tion, and their use in a method of diagnosis using NMR.
487858
Gries Heinz
Rosenberg Douwe
Weinmann Hans-Joachim
Marks & Clerk
Schering Aktiengesellschaft
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