Paramagnetic complexes of n-alkyl-n-hydroxylamides of...

Details Paramagnetic complexes of n-alkyl-n-hydroxylamides of... Paramagnetic complexes of n-alkyl-n-hydroxylamides of...

C - Chemistry, Metallurgy

07

F

C07F 5/00 (2006.01) A61K 9/107 (2006.01) A61K 49/00 (2006.01) A61K 49/18 (2006.01) C07F 13/00 (2006.01) C07F 15/02 (2006.01)

Patent

CA 2205232

Emulsions of paramagnetic contrast agents, and processes of making and using them are disclosed. The emulsions contain water, a dispersed oil phase and a complex of a paramagnetic metal ion and an organic acid chelator, for example DTPA (diethylenetriaminepentaacetic acid), having a C10-C30 saturated aliphatic group and a hydroxyl group bonded to the nitrogen atom. The emulsions are very stable and therapeutically acceptable for intravenous administration to enhance MRI imaging.

L'invention porte sur des émulsions d'agents de contraste paramagnétiques et leurs procédés d'obtention et d'utilisation. Lesdites émulsions contiennent de l'eau, une phase huileuse dispersée et un complexe d'ion métallique paramagnétique et d'un chélateur d'acide organique, par exemple du DTPA (acide diéthylèntriaminepentaacétique) comportant un groupe aliphatique saturé C¿10?-C¿30? et un groupe hydroxyle lié à l'atome d'azote. Ces émulsions très stables et thérapeutiquement acceptables s'administrent per voie intraveineuse pour améliorer l'imagerie par RMN.

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