Paramagnetic particles that provide improved relaxivity

Details Paramagnetic particles that provide improved relaxivity Paramagnetic particles that provide improved relaxivity

A - Human Necessities

61

K

A61K 49/18 (2006.01) A61B 5/055 (2006.01)

Patent

CA 2480209

An improved contrast agent for magnetic resonance imaging comprises particles to each of which is coupled a multiplicity of chelating agents containing paramagnetic ions. In the improved agent, the position of the ion is offset from the surface of the particle so as to improve the relaxivity imparted by the contrast agent. A tether offsetting the chelate from the surface of the particle may optionally contain cleavage sites permitting more facile excretion of the chelated paramagnetic ion.

L'invention concerne un agent de contraste amélioré, destiné à l'imagerie par résonance magnétique nucléaire, comprenant des particules, chacune de ces particules étant couplée à une multiplicité de molécules d'agents de chélation contenant des ions paramagnétiques. Dans cet agent amélioré, la position de l'ion est décalée par rapport à la surface de la particule de façon à améliorer la vitesse de relaxation apportée par l'agent de contraste. Un lien de décalage du chélate par rapport à la surface de la particule peut éventuellement contenir des sites de scission permettant une élimination plus facile de l'ion paramagnétique chélaté.

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