Paramyxovirus vector encoding angiogenesis gene and use thereof

Details Paramyxovirus vector encoding angiogenesis gene and use thereof Paramyxovirus vector encoding angiogenesis gene and use thereof

C - Chemistry, Metallurgy

12

N

C12N 15/86 (2006.01) A61K 48/00 (2006.01) C07K 14/50 (2006.01)

Patent

CA 2430112

The present invention provides Paramyxovirus vectors encoding angiogenic genes and use of the same. The use of Paramyxovirus vectors enables effective transfer of angiogenic genes into individual tissues. FGF2 gene transferred into ischemic tissues in vivo induces expression of angiogenic genes without causing edema, and prevents necrosis due to ischemia. The vectors of the present invention are suitable for gene therapy targeted to ischemic tissues.

L'invention concerne un vecteur paramyxovirus codant pour un gène angiogénèse. L'utilisation du vecteur paramyxovirus permet de transférer efficacement le gène angiogénèse dans un tissu individuel. Le gène FGF2 administré in vivo exprime le gène angiogénèse n'entraînant aucun oedème dans un tissu ischémique, ce qui permet de prévenir la nécrose due à l'ischémie. L'utilisation de ce vecteur convient bien en thérapie génique ciblant les tissus ischémiques.

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