Parathyroid hormone analogues and methods of use

Details Parathyroid hormone analogues and methods of use Parathyroid hormone analogues and methods of use

A - Human Necessities

61

K

A61K 38/29 (2006.01) A61K 9/08 (2006.01) A61K 38/12 (2006.01) A61P 19/08 (2006.01)

Patent

CA 2659846

The present invention is directed to novel methods of treating a subject with a bone deficit disorder. The methods generally include administering to a subject in need thereof a pharmaceutically acceptable formulation comprising a parathyroid hormone (PTH) peptide analogue in a daily dose sufficient to result in an effective pharmacokinetic profile and maintained adenylate cyclase activity, while simultaneously reducing undesirable side effects.

L'invention concerne de nouveaux procédés de traitement d'un patient présentant un trouble de déficience osseuse. Ces procédés consistent généralement à administrer à un patient nécessitant un tel traitement une formulation pharmaceutiquement acceptable comprenant un analogue peptidique de l'hormone parathyroïdienne (PTH) dans une dose journalière suffisante pour obtenir un profil pharmacocinétique efficace et pour maintenir l'activité de l'adénylate cyclase, tout en réduisant simultanément les effets secondaires indésirables.

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