Parathyroid hormone analogues and methods of use

A - Human Necessities – 61 – K

Patent

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Details

A61K 38/29 (2006.01) A61K 31/59 (2006.01) A61K 33/06 (2006.01)

Patent

CA 2621264

The present invention is directed to novel methods of treating a subject with a bone deficit disorder. The methods generally include administering to a subject in need thereof a pharmaceutically acceptable formulation comprising a parathyroid hormone (PTH) peptide analogue in a daily dose of 2 µg to 60 µg, wherein said PTH peptide analogue has a reduced phospholipase-C activity and maintains adenylate cyclase activity.

La présente concerne de nouveaux procédés de traitement d'individus atteints d'un trouble du déficit osseux. Lesdits procédés impliquent de manière générale d'administrer, à un individu le nécessitant, une formulation pharmaceutiquement acceptable comprenant un analogue peptidique d'hormone parathyroïdienne (PTH) en une dose quotidienne allant de 2 µg à 60 µg, ledit analogue faisant preuve d'une activité de phospholipase-C réduite et d'une activité d'adénylate cyclase stable.

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