Parathyroid hormone analogues for the treatment of osteoporosis

Details Parathyroid hormone analogues for the treatment of osteoporosis Parathyroid hormone analogues for the treatment of osteoporosis

C - Chemistry, Metallurgy

07

K

C07K 14/635 (2006.01) A01K 29/00 (2006.01) A61D 99/00 (2006.01) C12Q 1/00 (2006.01)

Patent

CA 2599885

This invention describes analogues of human parathyroid hormone which have increased activities in bone restoration, and increased bioavailabilities. The peptides described are derivatives of hPTH-(1-31) which are cyclized for example, by formation of Lactams between either Glu22 and Lys26 or Lys26 and Asp30. In addition, the natural Lys27 may be substituted by either a Leu or other hydrophobic residues, such as Ile, norleucine, Met, Val, Ala, Trp, or Phe. Typically, these analogues have enhanced abilities to stimulate adenylyl cyclase in rat osteosarcoma cells, and show increased activities in bone restoration, using the ovariectomized rat model. The analogues also show enhanced activities and bioavailabilities, as demonstrated by their hypotensive effects in the rat. An assay which correlates hypotensive activity with osteogenic activity is also described.

Affiliated with

Also associated with

Rating

Parathyroid hormone analogues for the treatment of osteoporosis does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Parathyroid hormone analogues for the treatment of osteoporosis, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Parathyroid hormone analogues for the treatment of osteoporosis will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1509168