Parathyroid hormone derivatives

Details Parathyroid hormone derivatives Parathyroid hormone derivatives

C - Chemistry, Metallurgy

07

K

C07K 14/635 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2052375

Disclosed are peptides and salts thereof represented by general formul R1-Val-Ser-Glu-Ile-Gln-Leu-R2-His-Asn-R3-R4-R5- His-Leu-Asn-Ser-R6-R7-Arg-R8-Glu-R9-Leu-R10-R11-R12- Leu-Gln-Asp-Val-His-Asn-R13 wherein R1 represents Ser or Aib; R2 represents Met or a naturally occurring hydrophobic amino acid; R3 represents Leu, Ser, Lys or an aromatic amino acid; R4 represents Gly or a D-.alpha.-amino acid; R5 represents Lys or Leu; R6 represents Met or a naturally occurring hydrophobic amino acid; R7 represents Glu or a basic amino acid; R8 represents Val or basic amino acid; R9 represents Trp or 2- (1,3-dithiolane-2-yl)Trp; R10 represents Arg or His; R11 represents Lys or His; R12 represents Lys, Gln or Leu; and R13 represents Phe or Phe-NH2; except that simultaneously R1 consists of Ser, R2 consists of Met, R3 consists of Leu, R4 consists of Gly, D-Ala or D-Pro, R5 consists of Lys, R6 consists of Met, R7 consists of Glu, R8 consists of Val, R9 consists of Trp, R10 consists of Arg, R11 consists of Lys and R12 consists of Lys. The parathyroid hormone (1-34) analogues are useful in hormone therapy.

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