Parathyroid hormone formulation

Details Parathyroid hormone formulation Parathyroid hormone formulation

A - Human Necessities

61

K

A61K 38/29 (2006.01) A61K 9/19 (2006.01) A61K 47/12 (2006.01) A61K 47/26 (2006.01)

Patent

CA 2179207

Described herein are preparations containing parathyroid hormone that has been stabilized with an excipient and buffering agent. Preferred preparations incorporate human PTH(1-84), mannitol as excipient and citrate as buffering agent, and are incorporated in vials as a freeze-dried powder for reconstitution to treat osteoporosis.

Sont décrites des préparations contenant de l'hormone parathyroïde qui a été stabilisée avec un excipient et un agent de tamponnage. Les préparations préférées comprennent de l'hormone parathyroïde humaine (1-84), du mannitol comme excipient et du citrate comme agent de tamponnage, et sont incorporées dans des flacons sous forme de poudre lyophilisée destinée à être reconstituée pour traiter l'ostéoporose.

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