C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/16 (2006.01) A61K 31/7088 (2006.01) A61K 38/29 (2006.01) A61K 48/00 (2006.01) A61K 49/00 (2006.01) A61P 17/00 (2006.01) A61P 19/10 (2006.01) A61P 35/00 (2006.01) C07K 14/635 (2006.01) C07K 16/26 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2498308
Novel parathyroid hormone polypeptides and biologically active fragments thereof are disclosed along with nucleic acid molecules encoding same. In particular, parathyroid hormone polypeptides and biologically active fragments (and encoding nucleic acid molecules) derived from fish species (eg Japanese pufferfish (Fugu rubripes)) are disclosed. Such polypeptides and fragments may be used for treatment of diseases associated with abnormal calcium homeostasis (eg osteoporosis, osteopenia, Paget's disease, bone cancer, hyperparathyroidism, hypoparathyroidism, hypercalcemia, psoriasis and other skin-related conditions).
L'invention concerne de nouveaux polypeptides d'hormone parathyroïdienne, leurs fragments biologiquement actifs et des molécules d'acides nucléiques codant ces polypeptides. Elle concerne, en particulier, des polypeptides d'hormone parathyroïdienne et des fragments biologiquement actifs (et codant les molécules d'acide nucléique) provenant d'espèces de poissons telles que le poisson-globe japonais, Fugu rubripes. On peut utiliser ces polypeptides et ces fragments afin de traiter des maladies associées à une homéostase calcique anormale, par exemple, l'ostéoporose, l'ostéopénie, la maladie de Paget, le cancer des os, l'hyperparathyroïdisme, l'hypoparathyroïdisme, l'hypercalcémie, le psoriasis ou d'autres troubles associés à la peau.
Danks Janine Athalie
Zajac Jeffrey David
Bennett Jones Llp
Teeleostin Limited
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