Parenteral formulations comprising a beta-cyclodextrin and a...

Details Parenteral formulations comprising a beta-cyclodextrin and a... Parenteral formulations comprising a beta-cyclodextrin and a...

A - Human Necessities

61

K

A61K 31/439 (2006.01) A61K 47/10 (2006.01) A61K 47/40 (2006.01) A61K 47/48 (2006.01)

Patent

CA 2554346

The present invention is directed to pharmaceutical compositions containing a therapeutically effective amount of an Active Pharmaceutical Ingredient ("API"), a pharmaceutically acceptable cyclodextrin and a pharmaceutically acceptable preservative. The invention is also directed to pharmaceutical compositions of the compounds of Formula (I) wherein R2 is selected from the group consisting of methyl, ethyl, isopropyl, sec-butyl and tert-butyland a pharmaceutically acceptable cyclodextrin and preservative. Formula (I): In particular, the invention is directed to pharmaceutical compositions of the compound of Formula la, and a pharmaceutically acceptable cyclodextrin and a preservative.

La présente invention se rapporte à des compositions pharmaceutiques contenant une quantité thérapeutiquement efficace d'un ingrédient pharmaceutique actif ("API"), une cyclodextrine pharmaceutiquement acceptable et un conservateur pharmaceutiquement acceptable. L'invention se rapporte également à des compositions pharmaceutiques des composés représentés par la formule (I), où R<SUP>2</SUP> est sélectionné dans le groupe constitué par méthyle, éthyle, isopropyle, <i>sec</i>-butyle et <i>tert</i>-butyle et une cyclodextrine et un conservateur pharmaceutiquement acceptables. En particulier, l'invention se rapporte à des compositions pharmaceutiques du composé représenté par la formule (Ia), et à une cyclodextrine et à un conservateur pharmaceutiquement acceptables.

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