Parenteral formulations of...

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A - Human Necessities

61

K

167/223

A61K 31/495 (2006.01) A61K 47/12 (2006.01) A61K 47/26 (2006.01)

Patent

CA 2001170

26460-FF ABSTRACT OF THE DISCLOSURE A pharmaceutical formulation suitable for parenteral (preferably intravenous) administration includes an effective amount of 1-diphenylmethyl-4-[(2-(4-methyl- phenyl)-5-methyl-1H-imidazol-4-yl)methyl]piperazine and a suitable amount of an acid to generate a pharmaceutically acceptable salt having a pH above about 3.0 and a solubility above about 4.0 mg/ml. The intravenous formulation optionally includes a suitable tonicifier in a quantity sufficient to achieve isotonicity with body fluids. The salt is formed in situ during the formulation process. The salt of tartaric acid is preferred; suitable salts for lower concentration dosages are the citric acid and methane sulphonic acid salts. 0304M 26460-FF

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