Parenteral pharmaceutical compositions containing gf120918a

A - Human Necessities – 61 – K

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A61K 31/47 (2006.01) A61K 31/473 (2006.01) A61K 47/10 (2006.01) A61K 47/12 (2006.01) A61K 47/14 (2006.01) A61K 47/16 (2006.01) A61K 47/26 (2006.01) A61K 47/44 (2006.01)

Patent

CA 2201628

Pharmaceutical compositions that prevent or minimize precipitation upon injection or infusion, comprising: a) a safe and therapeutically effective amount of N-{4-[2-1,2,3,4-tetrahydro-6,7-dimethoxy-2-isoquinolinyl)-ethyl]- phenyl}-9,10-dihydro-5-methoxy-9-oxo-4-acridine carboxamide and its physiologically acceptable salts and solvates; b) a safe and effective amount of a surfactant; c) a buffer system; and d) a pharmaceutically acceptable carrier.

Cette invention se rapporte à des compositions pharmaceutiques dont la précipitation est empêchée ou réduite à un niveau minimum lors de leur injection ou de leur administration par perfusion. Ces compositions comprennent: (a) une quantité sûre et thérapeutiquement efficace de N-{4-[2-1,2,3,4-tétrahydro-6,7-diméthoxy-2-isoquinolinyl)-éthyl]-phényl}-9,10-dihydro-5-méthoxy-9-oxo-4-acridine carboxamide et ses sels et solvates physiologiquement acceptables; (b) une quantité sûre et efficace d'un tensioactif; (c) un système tampon et (d) un excipient acceptable sur le plan pharmaceutique.

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