Parmaceutical agents and methods for tissue and vascular...

Details Parmaceutical agents and methods for tissue and vascular... Parmaceutical agents and methods for tissue and vascular...

C - Chemistry, Metallurgy

07

K

C07K 19/00 (2006.01) A61K 38/17 (2006.01) A61K 38/18 (2006.01) A61P 1/16 (2006.01) A61P 9/00 (2006.01) A61P 11/00 (2006.01) A61P 13/12 (2006.01) A61P 43/00 (2006.01) C07K 14/47 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2470063

It is found out that when a hepatocyte growth factor (HGF) receptor binds to a novel mucin-like protein, the expression of the function of the HGF/HGF receptor is regulated and thus the HGF-dependent cell proliferation and tissue and vessel regeneration/neogenesis are inhibited. It is further found out that various diseases including liver diseases can be treated by inhibiting the binding of the HGF receptor to the mucin-like protein.

Il a été découvert que lorsqu'un récepteur de facteur de croissance hépatocyte (HGF) fixe une nouvelle protéine de type mucine, l'expression de la fonction du récepteur HGF/HGF est régulée et qu'ainsi, la prolifération cellulaire HGF dépendante et la régénération/néogenèse tissulaire et vasculaire sont inhibées. Il a également été découvert que diverses pathologies, y compris des affections hépatiques peuvent être traitées par inhibition de la fixation du récepteur de HGF sur la protéine de type mucine.

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