Paroxetine compositions and processes for making the same

Details Paroxetine compositions and processes for making the same Paroxetine compositions and processes for making the same

A - Human Necessities

61

K

A61K 31/4525 (2006.01) A61K 9/00 (2006.01) A61K 9/20 (2006.01) A61K 9/46 (2006.01) A61K 9/50 (2006.01)

Patent

CA 2418038

Paroxetine salt compositions having improved stability are formed by controlling the pH to 6.5 or less. The compositions can be made with the air of water without significant coloration problems. The paroxetine salt include paroxetine hydrochloride salts but preferably use paroxetine sulfonate salts such as paroxetine methane sulfonate.

L'invention concerne des compositions à base de sel de paroxetine présentant une stabilité améliorée, formées par régulation du pH à 6,5 au plus. Ces compositions peuvent être obtenues à l'aide d'eau, sans problèmes majeurs de coloration. Ces sels de paroxetine comprennent également des sels de chlorhydrate de paroxetine, mais utilisent plus avantageusement des sels sulfonés de paroxetine, tel que du méthane sulfonate de paroxetine.

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