Parp inhibitors, pharmaceutical compositions comprising...

Details Parp inhibitors, pharmaceutical compositions comprising... Parp inhibitors, pharmaceutical compositions comprising...

C - Chemistry, Metallurgy

07

G

C07G 99/00 (2009.01) A61K 31/00 (2006.01) A61K 31/192 (2006.01) A61K 31/4365 (2006.01) A61K 31/472 (2006.01) A61K 31/473 (2006.01) A61K 31/501 (2006.01) A61K 31/5025 (2006.01) A61K 45/00 (2006.01) A61P 1/00 (2006.01) A61P 1/04 (2006.01) A61P 3/10 (2006.01) A61P 7/00 (2006.01) A61P 9/00 (2006.01) A61P 9/04 (2006.01) A61P 9/10 (2006.01) A61P 13/12 (2006.01) A61P 17/00 (2006.01) A61P 19/02 (2006.01) A61P 19/10 (2006.01) A61P 25/00 (2006.01) A61P 25/04 (2006.01) A61P 25/14 (2006.01) A61P 25/16 (2006.01) A61P 25

Patent

CA 2294074

The present invention relates to PARP inhibitors, pharmaceutical compositions comprising the same, and methods of using the same to treat tissue damage resulting from cell damage or death due to necrosis or apoptosis, effect neuronal activities not mediated by NMDA toxicity; to treat neural tissue damage resulting from ischemia and reperfusion injury, neurological disorders and neurodegenerative diseases; to prevent or treat vascular stroke; to treat or prevent cardiovascular disorders; to treat other conditions and/or disorders such as age-related macular degeneration, AIDS and other immune senescence diseases, arthritis, atherosclerosis, cachexia, cancer, degenerative diseases of skeletal muscle involving replicative senescence, diabetes, head trauma, immune senescence, inflammatory bowel disorders (such as colitis and Crohn's disease), muscular dystrophy, osteoarthritis, osteoporosis, chronic and/or acute pain (such as neuropathic pain), renal failure, retinal ischemia, septic shock (such as endotoxic shock), organ damage due to transplantation, and skin aging; to extend the lifespan and proliferative capacity of cells; to alter gene expression of senescent cells; or to radiosensitize hypoxic tumor cells.

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