Partial or full a1 agonists - n6 heterocyclic 5'-thio...

Details Partial or full a1 agonists - n6 heterocyclic 5'-thio... Partial or full a1 agonists - n6 heterocyclic 5'-thio...

C - Chemistry, Metallurgy

07

H

C07H 19/16 (2006.01) A61K 31/7076 (2006.01) A61P 9/00 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2389264

N6 heterocyclic 5' modified adenosine derivatives that are adenosine A1 receptor partial or full agonists, and as such, are useful for modifying cardiac activity, modifying adipocyte function, treating central nervous system disorders, and treating diabetic disorders and obesity in mammals, and especially in humans.

L'invention concerne des dérivés de N<6>-adénosine hétérocyclique substituée en 5'-thio, qui constituent des agonistes entiers ou partiels du récepteur A1, utiles, en tant que tels, pour la modification de l'activité cardiaque, de la fonction des adipocytes, pour le traitement des troubles du système nerveux central, de troubles diabétiques et de l'obésité chez les mammifères, notamment les humains.

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