Partial peptide mimetics and methods

Details Partial peptide mimetics and methods Partial peptide mimetics and methods

C - Chemistry, Metallurgy

07

K

C07K 14/52 (2006.01) A61K 38/04 (2006.01) A61K 38/19 (2006.01) A61P 31/04 (2006.01) A61P 35/00 (2006.01) C07K 7/04 (2006.01) C07K 7/08 (2006.01) C07K 14/00 (2006.01) C07K 19/00 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2476427

Partial peptide mimetics and methods of making and using, wherein the partial peptide mimetics have a first amino acid sequence comprising ANIKLSVQMKL (SEQ ID NO: 8), a homolog thereof, or a segment of SEQ ID NO: 8 or a homolog thereof, a second amino acid sequence comprising IIVKLND (SEQ ID NO:2), a homolog thereof, or a segment of SEQ ID NO:2 or a homolog thereof, and a .beta.-turn inducing scaffold bonded between the first and second amino acid sequences.

L'invention a trait à des mimétiques peptidiques partiels et à des procédés de production et d'utilisation de ceux-ci. Les mimétiques peptidiques partiels contiennent une première séquence d'acides aminés comprenant ANIKLSVQMKL (SEQ ID NO: 8), un homologue de cette dernière, ou un segment de SEQ ID NO: 8 ou un homologue de ce dernier, une seconde séquence d'acides aminés comprenant IIVKLND (SEQ ID NO:2), un homologue de cette dernière, ou un segment de SEQ ID NO:2 ou un homologue de ce dernier, ainsi qu'un squelette inducteur de coude bêta lié entre les première et seconde séquences d'acides aminés.

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