Partial peptide of lacritin

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 14/475 (2006.01) C12N 5/07 (2010.01) A61K 38/17 (2006.01) A61K 38/18 (2006.01) C07K 14/47 (2006.01) C12N 15/09 (2006.01)

Patent

CA 2718706

The present invention aims to provide a polypeptide having a partial sequence of lacritin, which is capable of promoting adhesion between a cell and an extracellular matrix; and a polypeptide having a partial sequence of lacritin, which has an action to promote tear fluid secretion. The present invention provides a polypeptide comprising the amino acid sequence of SEQ ID NO: 1, which is a particular partial sequence of lacritin, and having an amino acid length of not more than 70 residues. The polypeptide of the present invention can promote adhesion between a cell and an extracellular matrix. The polypeptide of the present invention can promote tear fluid secretion from lacrimal gland acinar cells.

L'invention porte sur un polypeptide comprenant une séquence partielle de la lacritine, qui peut favoriser l'adhérence entre une cellule et une matrice extracellulaire. L'invention porte également sur un polypeptide comprenant une séquence partielle de la lacritine, qui a une activité favorisant la sécrétion des larmes. De façon spécifique, l'invention porte sur un polypeptide qui comprend la séquence d'acides aminés représentée dans SEQ ID No : 1 (qui est une séquence partielle spécifique de la lacritine) et qui a un nombre d'acides aminés de 70 résidus ou moins. Le polypeptide peut favoriser l'adhérence entre une cellule et une matrice extracellulaire. Le polypeptide peut également favoriser la sécrétion de larmes dans une cellule acineuse des glandes lacrymales.

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