Partially fused pellet as a subcutaneous drug delivery

Details Partially fused pellet as a subcutaneous drug delivery Partially fused pellet as a subcutaneous drug delivery

A - Human Necessities

61

K

167/164, 167/103

A61K 9/24 (2006.01) A61K 9/00 (2006.01) A61K 9/16 (2006.01) A61K 38/11 (2006.01) A61K 38/22 (2006.01)

Patent

CA 1337588

A bioerodible pellet capable of administering an even and continuous dose of a peptide over a period of up to a year, when subcutaneously implanted, is provided. The bioerodible implant is a partially-fused pellet, which pellet has a peptide drug homogeneously-bound in a matrix of a melted and recrystallized, nonpolymer carrier. Preferably, the nonpolymer carrier is a steroid and in particular is cholesterol or a cholesterol derivative. In one embodiment, the peptide drug is growth hormone-releasing hormone. A method for making the bioerodible pellet also is provided.

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