Partially loaded antibodies and methods of their conjugation

Details Partially loaded antibodies and methods of their conjugation Partially loaded antibodies and methods of their conjugation

C - Chemistry, Metallurgy

07

K

C07K 16/00 (2006.01) A61K 38/05 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01) A61P 31/00 (2006.01) A61P 35/00 (2006.01) A61P 37/02 (2006.01) C07K 1/107 (2006.01) C07K 1/14 (2006.01) C07K 14/52 (2006.01) C07K 14/575 (2006.01) C07K 14/705 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2558399

A protein containing one or more activatable groups, e.g., an antibody, is subjected to partial or complete reduction of one or more such bonds to form reactive groups; the resulting protein is reacted with a drug which is reactive with some of the reactive groups, such as certain radiometals, chelating agents, and toxins, so as to form a conjugate useful in, e.g., in vitro diagnosis, in vivo imaging, and therapy.

Une protéine contenant un ou plusieurs groupes activables, par ex. un anticorps, est soumise à la réduction partielle ou complète d'une ou plusieurs liaisons pour former des groupes réactifs. La protéine résultante est mise en réaction avec un médicament qui réagit avec certains des groupes réactifs, tels que certains radiométaux, des agents de chélation et des toxines, de manière à former un conjugué utile, par ex. pour le diagnostic in vitro, l'imagerie in vivo et la thérapie.

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