Partially retro-inverted decapeptide as a specific renin...

Details Partially retro-inverted decapeptide as a specific renin... Partially retro-inverted decapeptide as a specific renin...

C - Chemistry, Metallurgy

07

K

530/7.14

C07K 7/14 (2006.01) C07K 5/02 (2006.01) C07K 7/02 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1249396

PARTIALLY RETRO-INVERTED DECAPEPTIDE AS A SPECIFIC RENIN INHIBITOR WITH HIGH RESISTANCE TO ENZYMATIC HYDROLYSIS ABSTRACT Synthesis of an analogue of the (5-14) decapeptide of equine angiotensinogen partially retro-inverted at the Phe-Phe bond, of formula: Image The retro-inverso analogue inhibits renin with high resistance to enzymatic degradation, and can be used in the treatment of renin-dependent hypertension.

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