Particle aggregation method and apparatus

Details Particle aggregation method and apparatus Particle aggregation method and apparatus

G - Physics

01

N

G01N 33/543 (2006.01) B01D 21/00 (2006.01) B01D 43/00 (2006.01) B01F 11/02 (2006.01) B01J 19/10 (2006.01) C02F 1/36 (2006.01) G01N 29/02 (2006.01) G01N 33/555 (2006.01)

Patent

CA 2130276

2130276 9319367 PCTABS00026 A sample (e.g. 52) of liquid with suspended particles is contained in a tube (10) and subjected to a standing wave ultrasound field transverse to the tube (10), the standing wave exhibiting a progressive change in pressure amplitude transverse to the tube, so that particles in suspension are displaced transversely of the tube to one or more predetermined regions: exposure of the sample to the standing wave is then terminated and the particles are allowed to settle, and inspected to determine whether they remain aggregated or whether they dissociate. The ultrasound field is produced by a transducer (20) of tubular form encircling the tube (10). The invention may be used for the agglutination of particles or cells via cross-bridging molecules in immuno-agglutination assays.

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