Particle and preparation containing the particle

Details Particle and preparation containing the particle Particle and preparation containing the particle

A - Human Necessities

61

K

A61K 38/00 (2006.01) A61K 9/72 (2006.01) A61K 47/24 (2006.01) A61K 47/26 (2006.01) A61K 47/38 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2602007

Particles of 0.01 to 20 µm average diameter comprising tert-butyl (4R)-4- {[((1R)-2-[(1-benzylpiperidin-4-yl)amino]-1-{[(cyclohexylmethyl)thio]methyl}-2- oxoethyl)amino]carbonyl}-1,3-thiazolidine-3-carboxylate. Preparations comprising the particles excel in transition into the lungs by inhalation and excel in dispersibility as particles, so that handling thereof is easy to thereby enable use of the compound as transpulmonary preparations.

La présente invention décrit des particules de diamètre moyen 0,01 à 20 µm comprenant du tert-butyl-(4R)-4-{[((1R)-2-[(1-benzylpipéridin-4-yl)amino]-1-{[(cyclohexylméthyl)thio]méthyl}-2-oxoéthyl)amino]carbonyl}-1,3-thiazolidine-3-carboxylate. Des préparations comprenant lesdites particules présentent d~excellentes caractéristiques de transport dans les poumons et d~aptitude à la dispersion en tant que particules, de sorte qu~il est facile de les manipuler de manière à pouvoir utiliser le composé dans le cadre de préparations transpulmonaires.

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