A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/21 (2006.01) A61K 39/12 (2006.01) C07K 14/16 (2006.01) C07K 16/00 (2006.01)
Patent
CA 2481980
This invention provides a first composition comprising a pharmaceutically acceptable particle and a stable HIV-l prefusion envelope glycoprotein trimeric complex operably affixed thereto. This invention further provides a second composition comprising (a) a pharmaceutically acceptable particle, (b) an antigen, and (c) an agent which is operably affixed to the particle and is specifically bound to the antigen, whereby the antigen is operably bound to the particle. Finally, this invention provides related nucleic acids, vectors, cells, compositions, production methods, and prophylactic and therapeutic methods.
L'invention concerne une première composition comprenant une particule pharmaceutiquement acceptable et un complexe stable, trimére de la glycoprotéine de l'enveloppe de VIH-1, apposé de manière fonctionnelle sur ladite particule. L'invention concerne, de plus, une seconde composition comprenant (a) une particule pharmaceutiquement acceptable, (b) un antigène et (c) un agent apposé de manière fonctionnelle sur la particule et qui est lié de manière spécifique à l'antigène. Ledit antigène est lié de manière spécifique à la particule. Enfin, l'invention concerne des acides nucléiques, des vecteurs, des cellules, des compositions, des procédés de production et des procédés prophylactiques et thérapeutiques.
Gardner Jason
Maddon Paul J.
Olson William C.
Schulke Norbert
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Progenics Pharmaceuticals Inc.
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