Particle compositions with a pre-selected cell...

Details Particle compositions with a pre-selected cell... Particle compositions with a pre-selected cell...

A - Human Necessities

61

K

A61K 9/51 (2006.01) A61K 47/48 (2006.01)

Patent

CA 2732252

A method of formulating a particle composition having a pre-selected cell internalization mode involves selecting a target cell having surface receptors and obtaining particles that have i) surface moieties, that have an affinity for or are capable of binding to the surface receptors of the cell and ii) a preselected shape, where a surface distribution of the surface moieties on the particles and the shape of the particles are effective for the pre- selected cell internalization mode.

L'invention porte sur un procédé de formulation d'une composition de particules qui présente un mode d'internalisation de cellule présélectionné et qui entraîne la sélection d'une cellule cible ayant des récepteurs de surface et l'obtention de particules qui ont i) des fractions de surface, qui ont une affinité pour les récepteurs de surface de la cellule ou qui sont capables de s'y lier, et ii) une forme présélectionnée, la distribution de surface des fractions de surface sur les particules et la forme des particules étant efficaces pour le mode d'internalisation de cellule présélectionné.

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