A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/16 (2006.01)
Patent
CA 2426247
Preparation of particles of an active substance having a layer ofan additive at the particle surfaces, by dissolving both the active substance and the additive in a vehicle to form a target solution, and contacting the target solution with an anti-solvent fluid using a SEDSTM particle formation process, to cause the active substance and additive to coprecipitate. The additive is typically a protective additive, in particular a taste and/or odour masking agent. Also provided is a particulate coformulation made by the method, which has a finite gradient in the relative additive concentration, which concentration increases radially outwards from the active rich core to the additive-rich surface of the particles.
L'invention concerne un procédé permettant la préparation de particules comprenant un composant actif et une surface enrobée d'une couche d'additif. Ce procédé consiste à dissoudre le composant actif et l'additif dans un véhicule de manière à former une solution cible, et à faire entrer en contact cette solution cible avec un fluide anti-solvant en appliquant un processus de formation de particules SEDS?TM¿, afin de provoquer une co-précipitation du composant actif et de l'additif. L'additif est en général un additif de protection, en particulier un agent de masquage de goût ou d'odeur. L'invention concerne également une co-formulation particulaire obtenue par ce procédé, qui présente un gradient fini de concentration relative d'additif, cette concentration augmentant radialement vers l'extérieur entre le noyau à forte teneur de composant actif et la surface externe à forte teneur d'additif.
Hanna Mazen Hermiz
York Peter
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Nektar Therapeutics Uk Ltd.
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