Particle-induced ghrelin immune response

A - Human Necessities – 61 – K

Patent

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Details

A61K 47/48 (2006.01) A61P 3/04 (2006.01) A61P 3/06 (2006.01) C12N 15/86 (2006.01)

Patent

CA 2553594

The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a modified virus-like particle (VLP) comprising a VLP and particular peptides derived from ghrelin linked thereto. The invention also provides a process for producing the modified VLP. The modified VLPs of the invention are useful in the production of vaccines for the treatment of obesity and other disease associated with increased food- uptake or increased body weight and to efficiently induce immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context.

La présente invention se rapporte au domaine de la biologie moléculaire, de la virologie, de l'immunologie et de la médecine. La présente invention propose une pseudo-particule virale (VLP) modifiée comportant une VLP et des peptides particuliers liés à cette VLP et dérivés de ghréline. La présente invention propose également un procédé de production de la VLP modifiée. Les VLP modifiées selon l'invention sont utilisables dans la fabrication de vaccins destinés au traitement de l'obésité et d'autres maladies associées à une augmentation de la consommation d'aliments ou à une augmentation du poids corporel, et permettant d'induire efficacement des réponses immunitaires, et notamment des réponses anticorpales. Par ailleurs, les compositions selon l'invention sont utilisables notamment dans l'induction efficace de réponses immunitaires auto-spécifiques dans le contexte indiqué.

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