Particles comprising polymers with thioester bonds

A - Human Necessities – 61 – K

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Details

A61K 9/50 (2006.01) A61K 9/16 (2006.01)

Patent

CA 2721330

The present invention relates to particles suitable for delivery of active agents comprising a polymer containing thioester bonds which are obtained via the reaction of a thioic acid functionality and an unsaturated group. The polymer may be is linear, branched or crosslinked. The particles have an average diameter in the range of 10 nm to 1000 µm, preferably in the range of 100nm-100 µm. The particles may comprise an active agent selected from the group of nutrients, pharmaceuticals, proteins and peptides, vaccines, genetic materials, diagnostic agents or imaging agents. The present invention further relates to the use of the particles in dermatology, muscular skeletal, oncology, in vascular applications, in orthopaedics, in ophthamology, spinal, intestinal, pulmonary, nasal, or auricular.

La présente invention concerne des particules adaptées à lapport dagents actifs. Ces particules comprennent un polymère contenant des liaisons thioester qui sont obtenues par la réaction dune fonctionnalité dacide thioique et dun groupe insaturé. Ce polymère peut être linéaire, ramifié ou réticulé. Lesdites particules présentent un diamètre moyen compris entre 10 nm et 1 000 µm, de préférence entre 100 nm et 100 µm. Les particules peuvent comprendre un agent actif sélectionné dans le groupe des nutriments, des produits pharmaceutiques, des protéines et des peptides, des vaccins, des matériaux génétiques, des agents de diagnostic ou des agents dimagerie. La présente invention concerne en outre lutilisation desdites particules en dermatologie, pour le squelette musculaire, en oncologie, et dans des applications vasculaires, orthopédiques, ophtalmologiques, rachidiennes, intestinales, pulmonaires, nasales ou auriculaires.

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