Particles for cell targeting

A - Human Necessities – 61 – K

Patent

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Details

A61K 9/14 (2006.01) A61K 47/04 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01)

Patent

CA 2664400

Provided is a composition that includes oblate spheroidal particles comprising an active agent, such as a therapeutic or imaging agent, and a method for treating or monitoring a physiological condition, such as a disease, by administering the composition to a subject in need thereof. Also provided are methods for making particles that have a volume that can enhance the particles' adhesion to a target site in a subject's body for a pre-selected shape of the particles and methods for making particles that have a shape that can enhance particles' adhesion to a target site in a subject's body for a pre-selected volume of the particles.

L'invention propose une composition qui comprend des particules sphéroïdes aplaties comportant un agent actif, tel qu'un agent thérapeutique ou d'imagerie, et un procédé de traitement ou de surveillance d'un trouble physiologique, telle qu'une maladie, par administration de la composition à un sujet qui a besoin de celle-ci. Il est également proposé des procédés de préparation de particules qui ont un volume qui peut améliorer l'adhérence des particules à un site cible dans le corps d'un sujet pour une forme présélectionnée des particules, et des procédés de préparation des particules qui ont une forme qui peut améliorer l'adhérence des particules à un site cible dans le corps d'un sujet pour un volume présélectionné des particules.

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