Particles for immunoassays and methods for treating the same

Details Particles for immunoassays and methods for treating the same Particles for immunoassays and methods for treating the same

G - Physics

01

N

G01N 33/549 (2006.01) G01N 33/53 (2006.01) G01N 33/531 (2006.01) G01N 33/532 (2006.01) G01N 33/543 (2006.01)

Patent

CA 2411019

A method of treating particles to be used in immunoassays reduces interference in particle agglutination assays. For particles having covalently bound antibodies and residual NHS-ester or sNHS-ester groups on the surface, the reactive esters are treated with an aqueous mixture containing an amine compound of formula (I): H2N - R - X (I) The moiety -X is -NH2, -OH, or -CO2CH2CH3; and R is an alkyl group or an alkyl ether group. When -X is -NH2 or -CO2CH2CH3, R contains from 1 to 20 carbon atoms; and when -X is -OH, R contains from 4 to 20 carbon atoms.

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