Particles for inhalation having sustained release properties

Details Particles for inhalation having sustained release properties Particles for inhalation having sustained release properties

A - Human Necessities

61

K

A61K 9/14 (2006.01) A61K 9/72 (2006.01) A61K 38/28 (2006.01) A61K 47/12 (2006.01) A61K 47/18 (2006.01) A61K 47/24 (2006.01) A61P 3/10 (2006.01)

Patent

CA 2433335

The invention generally relates to a method for pulmonary delivery of therapeutic, prophylactic and diagnostic agents to a patient wherein the agent is released in a sustained fashion, and to particles suitable for use in the method. In particular, the invention relates to a method for the pulmonary delivery of a therapeutic, prophylactic or diagnostic agent comprising administering to the respiratory tract of a patient in need of treatment, prophylaxis or diagnosis an effective amount of particles comprising a therapeutic, prophylatic or diagnostic agent or any combination thereof in association with a charged lipid, wherein the charged lipid has an overall net charge which is opposite to that of the agent upon association with the agent. Release of the agent from the administered particles occurs in a sustained fashion.

De manière générale, l'invention se rapporte à une méthode d'administration pulmonaire d'agents thérapeutiques, prophylactiques et diagnostiques à un patient, ces agents étant libérés de manière prolongée, ainsi qu'à des particules pouvant être utilisées dans cette méthode. Plus particulièrement, l'invention concerne une méthode d'administration pulmonaire d'un agent thérapeutique, prophylactique ou diagnostique consistant à administrer, dans les voies respiratoires d'un patient nécessitant un traitement, une prophylaxie ou un diagnostic, une dose efficace de particules renfermant un agent thérapeutique, prophylactique ou diagnostique ou une combinaison quelconque de ces agents en association avec un lipide chargé, lequel présente une charge nette totale opposée à celle de l'agent après association avec cet agent. La libération dudit agent à partir des particules administrées s'opère de façon prolongée.

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