Particles, method of preparing said particles and uses thereof

Details Particles, method of preparing said particles and uses thereof Particles, method of preparing said particles and uses thereof

A - Human Necessities

61

K

A61K 9/50 (2006.01) A61K 9/127 (2006.01) B01J 13/00 (2006.01) B01J 13/02 (2006.01)

Patent

CA 2120359

Particles, especially colloidal particles, comprising an interior phase of a non-lamellar reversed cubic, intermediate or hexagonal liquid crystalline phase, or a homogeneous L3 phase, and a surface phase of a lamellar crystalline or liquid crystalline phase, or an L3 phase. A method of preparing such particles by creating a local dispersible phase, within the homogeneous phase, preferably by means of a fragmentation agent, and fragmentating the homogeneous phase so as to form said surface phase. Several medical as well as non-medical uses of the particles referred to, e.g. as an antigen-presenting system, as a delivery system for anticancer, antifungal and antimicrobial drugs, and as carriers of nucleic acids or nucleotides.

Particules, particulièrement particules colloïdales, comprenant une phase intérieure constituée par une phase cristalline liquide hexagonale ou intermédiaire, cubique inversée non lamellaire ou par une phase L3 homogène, ainsi qu'une phase de surface constituée par une phase cristalline liquide ou cristalline lamellaire, ou par une phase L3. Procédé de préparation desdites particules en créant une phase locale dispersible à l'intérieur de la phase homogène, de préférence, au moyen d'un agent de fragmentation et en fragmentant ladite phase homogène de façon à constituer ladite phase de surface. Plusieurs utilisations médicales ou non médicales des particules décrites, par exemple, en tant que système présentant des antigènes, en tant que système d'administration de médicaments anticancers, antifongiques ou antimicrobiens et en tant que porteurs d'acides nucléiques ou de nucléotides.

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