Particles of hcv envelope proteins: use for vaccination

Details Particles of hcv envelope proteins: use for vaccination Particles of hcv envelope proteins: use for vaccination

C - Chemistry, Metallurgy

07

K

C07K 14/18 (2006.01) A61K 39/29 (2006.01) C07K 16/10 (2006.01) G01N 33/576 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2330526

The present invention is based on the finding that the envelope proteins of HCV induce a beneficial immune response in chronically HCV-infected chimpanzees. The immunization can preferentially be carried out using HCV envelope proteins in the form of particles which are produced in a detergent- assisted manner. The envelope proteins when presented as such to chronic HCV carriers are highly immunogenic and stimulate both the cellular and humoral immune response.

La présente invention se base sur la découverte que les protéines d'enveloppe du VHC (virus de l'hépatite C) induisent une réponse immunitaire bénéfique chez des chimpanzés infectés par le VHC. De préférence, on peut obtenir l'immunisation en utilisant des protéines d'enveloppe de VHC sous forme de particules produites par un procédé assisté par détergents. Lorsqu'elles sont mises en présence de porteurs de VHC chroniques, les protéines d'enveloppe sont hautement immunogènes et stimulent la réponse immunitaire cellulaire et humorale.

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