Particulate coformulations of active substances with excipients

Details Particulate coformulations of active substances with excipients Particulate coformulations of active substances with excipients

A - Human Necessities

61

K

A61K 9/16 (2006.01) A61K 9/20 (2006.01)

Patent

CA 2524773

A particulate coformulation, each particle comprising a core of an active substance surrounded by an excipient coating, the particles having a volume mean diameter of (10) ~m or less, which on oral administration releases the active substance at a rate such that the time (Tmax) taken to attain the maximum active concentration in the bloodstream is one hour or less. The coformulation may be made using a NektarTM SCF particle formation process.

L'invention concerne une coformulation particulaire dont chaque particule comprend un noyau de substance active entouré d'un revêtement excipient. Les particules présentent un diamètre moyen volumique inférieur ou égal à 10 microns qui, lors d'une administration orale libèrent leur principe actif à une vitesse, telle que la durée (T¿max?) prise pour atteindre la concentration active maximale dans la circulation sanguine est inférieure ou égale à une heure. La coformulation peut être effectuée au moyen d'un procédé de formation particulaire Nektar<SP>TM</SP> SCF.

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