Particulate composition of eletriptan

Details Particulate composition of eletriptan Particulate composition of eletriptan

A - Human Necessities

61

K

A61K 9/28 (2006.01) A61K 9/16 (2006.01) A61K 9/50 (2006.01) A61K 31/404 (2006.01)

Patent

CA 2417887

The invention provides a pharmaceutical composition in particulate form, suitable for oral administration, including a core containing eletriptan or a pharmaceutically acceptable salt thereof, the core being coated with a water- insoluble, permeable coating including one or more acrylic copolymer(s) containing trimethylammoniumethylmethacrylate groups, said composition being capable of achieving a sigmoidal pattern of controlled drug release. Such a pharmaceutical composition is particularly useful in the prevention of migraine recurrence.

L'invention concerne une composition pharmaceutique sous forme particulaire, adaptée à une administration par voie orale, comprenant un noyau contenant de l'élétriptan ou un sel pharmaceutiquement acceptable de celui-ci, le noyau étant enrobé d'un revêtement perméable, hydro-insoluble, comprenant des groupes triméthylammoniuméthylméthacrylate contenant un ou plusieurs copolymère(s) acrylique(s), ladite composition permettant de réaliser un modèle sigmoïde de libération commandée de médicaments. Une telle composition pharmaceutique est utile en particulier dans la prévention de la récurrence de la migraine.

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