Particulate compositions comprising alginate and/or alginic...

A - Human Necessities – 61 – K

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A61K 31/734 (2006.01) A61K 9/16 (2006.01) A61K 9/20 (2006.01) A61K 9/50 (2006.01)

Patent

CA 2616543

An ingestible particulate composition comprises: a. an alginate and/or alginic acid; b. a bicarbonate and/or carbonate; c. an organic acid; and d. an agglomerant, being a compound, such as a low molecular weight polyol, which allows the particulate composition to flow yet which substantially does not release fine particulates into the air. Resulting particulate compositions have excellent flow characteristics, dust suppression, organoleptic properties and stability. They are highly suitable for administration direction into a patient's mouth, and ingested to alleviate oesophageal and gastric conditions.

La présente invention concerne une composition particulaire ingérable comportant: a) un alginate et/ou de l'acide alginique; b) un bicarbonate et/ou carbonate; c) un acide organique; et d) un agent d'agrégation, qui est un composé, tel qu'un polyol de faible poids moléculaire, permettant l'écoulement de la composition particulaires mais pas la libération sensible de particules fines dans l'air. Les compositions particulaires obtenues présentent d'excellentes caractéristiques d'écoulement, de suppression de poussière, de propriétés organoleptiques et de stabilité. Elles conviennent parfaitement à l'administration directe dans la bouche d'un patient, et leur ingestion permet de soulager des conditions pathologiques oesophagiennes et gastriques.

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