Partners of ptb1 domain of fe65, preparation and uses

Details Partners of ptb1 domain of fe65, preparation and uses Partners of ptb1 domain of fe65, preparation and uses

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/00 (2006.01) C07K 14/47 (2006.01) C12N 15/11 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2399939

The invention concerns novel compounds and their pharmaceutical, diagnostic use or as pharmacological target. More particularly, it concerns the identification of partners of FE65 and the use thereof, or any compound capable of modulating, at least partly, their interaction with FE65 to regulate FE65 activity, and in particular the phenomenon of intracellular transport or of APP endocytosis.

La présente invention concerne de nouveaux composés et leur utilisation pharmaceutique, diagnostique ou comme cible pharmacologique. Plus particulièrement, la présente invention décrit l'identification de partenaires de la protéine FE65 et l'utilisation de ceux-ci, ou de tout composé capable de moduler, au moins partiellement, leur interaction avec FE65, pour réguler l'activité de FE65, et notamment le phénomène de transport intracellulaire ou d'endocytose de l'APP.

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