A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 35/76 (2006.01) C12N 7/00 (2006.01)
Patent
CA 2710889
A parvovirus characterized by a CpG-enriched genome, wherein the genome contains at least 2 additional CpG inserts that are not present in the wild type genome is described as well as the use of said parvovirus, e.g., a parvovirus based on parvovirus H1, LuIII, Mouse minute virus (MMV), Mouse parvovirus (MPV), Rat minute virus (RMV), Rat parvovirus (RPV), Rat virus (RV), vectors based on the foregoing viral species, and/or cells capable of actively producing the foregoing viral species for the preparation of a pharmaceutical composition, e.g., for the treatment of cancer, preferably pancreas carcinoma, hepatoma or lymphoma.
L'invention concerne un parvovirus caractérisé par un génome enrichi en CpG, le génome contenant au moins 2 insertions CpG supplémentaires qui ne sont pas présentes dans le génome de type sauvage. L'invention concerne également l'utilisation dudit parvovirus, par ex., un parvovirus à base de parvovirus H1, un LuIII, un virus minute de souris (MMV), un parvovirus de souris (MPV), un virus minute de rat (RMV), un parvovirus de rat (RPV), un virus de rat (RV), des vecteurs à base des susdites espèces virales, et/ou des cellules pouvant activement produire les susdites espèces virales pour la préparation d'une composition pharmaceutique, par ex., pour le traitement du cancer, de préférence des carcinomes du pancréas, des hépatomes ou des lymphomes.
Aprahamian Marc
Giese Nathalia
Raykov Zahari
Rommelaere Jean
Deutsches Krebsforschungszentrum
Ruprecht-Karls-Universitaet Heidelberg
Smart & Biggar
LandOfFree
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