C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/86 (2006.01) C07K 14/015 (2006.01) C12N 5/10 (2006.01) C12N 7/00 (2006.01) C12N 7/02 (2006.01) C12N 15/866 (2006.01) G01N 33/569 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01) A61K 31/73 (1995.01)
Patent
CA 2158564
The invention provides a method of detecting the presence of a parvovirus in a sample comprising contacting the sample with a purified receptor for a parvovirus, and detecting the presence of binding of parvovirus to the receptor, the presence of binding indicating the presence of parvovirus in the sample. The present invention also provides methods of purifying and removing parvoviruses from samples. The invention further provides a composition comprising a globoside, or the parvovirus B19 binding domain of globoside,in a pharmaceutically acceptable carrier. Also provided are methods of preventing or treating parvovirus B19 infection in a human subject by preventing the binding of parvovirus B19 to P antigen and methods of gene therapy utilizing parvovirus B19 and the parvovirus B19 cellular receptor.
Brown Kevin E.
Young Neal S.
Department Of Health And Human Services
Gowling Lafleur Henderson Llp
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