Passivated and stabilized porous supports and methods for...

Details Passivated and stabilized porous supports and methods for... Passivated and stabilized porous supports and methods for...

B - Operations, Transporting

01

J

B01J 20/28 (2006.01) B01D 15/08 (2006.01) B01J 20/26 (2006.01) B01J 20/32 (2006.01) B01J 39/16 (2006.01) C07H 21/00 (2006.01) C07K 1/22 (2006.01) C07K 9/00 (2006.01) C08B 37/10 (2006.01) G01N 30/02 (2006.01) G01N 30/50 (2006.01)

Patent

CA 2138520

This invention relates generally to modified porous solid supports and processes for the preparation and use of same. In particular, passivated porous mineral oxide, polymeric, or polymer-coated mineral oxide supports are disclosed which are characterized by a reversible high sorptive capacity substantially unaccompanied by non-specific adsorption of or interaction with biomolecules. Passivation is achieved by use of a passivation mixture comprising a main monomer, a passivating monomer and a crosslinking agent, which mixture upon polymerization results in the substantial elimination of the undesirable non-specific interaction with biomolecules.

Cette invention se rapporte en général à des supports solides, poreux, modifiés et à leurs procédés de préparation et d'utilisation. L'invention se rapporte en particulier à des supports polymères, d'oxyde minéral poreux rendus passifs ou à des supports d'oxyde minéral revêtus de polymères et qui se caractérisent par une grande capacité de sorption réversible pratiquement non accompagnée d'adsorption non-spécifique de biomolécules ou d'interaction avec celles-ci. La passivation s'effectue à l'aide d'un mélange de passivation comprenant un monomère principal, un monomère de passivation et un agent de réticulation; ce mélange lors de la polymérisation se traduit par l'élimination effective de l'interaction non-spécifique indésirable avec des biomolécules.

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