A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/02 (2006.01) A61K 39/08 (2006.01) A61K 39/40 (2006.01) C07K 1/00 (2006.01) C07K 14/33 (2006.01) C07K 16/00 (2006.01) C07K 16/12 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2307331
The invention provides active and passive immunization methods for preventing and treating Clostridium difficile infection, which involve percutaneous administration of C. difficile toxin-neutralizing polyclonal immune globulin, C. difficile toxoids, or combinations thereof. Also provided by the invention are C. difficile toxoids, C. difficile toxin-neutralizing polyclonal immune globulin, and methods of identifying subjects that produce C. difficile toxin- neutralizing polyclonal immune globulin.
La présente invention porte sur des méthodes d'immunisation active et passive pour la prévention et le traitement de l'infection de Clostridium difficile, qui prévoient l'administration percutanée d'immunoglobuline polyclonal ayant la propriété de neutraliser les toxines de Clostridium difficile, les toxoïdes de Clostridium difficile ou leurs combinaisons. L'invention porte également sur des toxoïdes de Clostridium difficile, sur l'immunoglobuline polyclonal ayant la propriété de neutraliser les toxines de Clostridium difficile, ainsi que sur des méthodes permettant d'identifier les sujets générant ce type d'immunoglobuline.
Giannasca Paul
Lei Wende
Monath Thomas P.
Thomas William D. Jr.
Zhang Zhenxi
Mbm Intellectual Property Law Llp
Oravax Inc.
Sanofi Pasteur Biologics Co.
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