Passive immunization against clostridium difficile disease

Details Passive immunization against clostridium difficile disease Passive immunization against clostridium difficile disease

A - Human Necessities

61

K

A61K 39/02 (2006.01) A61K 39/08 (2006.01)

Patent

CA 2550108

The invention provides active and passive immunization methods for preventing and treating Clostridium Difficile infection, which involve percutaneous administration of C. difficile toxin-neutralizing polyclonal immune globulin, C. difficile toxoids, or combinations thereof. Also provided by the invention are C. difficile toxoids, C. difficile toxin-neutralizing polyclonal immune globulin, and methods of identifying subjects that produce C. difficile toxin- neutralizing polyclonal immune globulin.

L'invention concerne des méthodes d'immunisation active et passive pour prévenir et traiter l'infection à Clostridium difficile, consistant à administrer par voie percutanée l'immunoglobuline polyclonale neutralisant les toxines de C. difficile, des toxoïdes de C. difficile ou des combinaisons de ceux-ci. Cette invention concerne également des toxoïdes de C. difficile, l'immunoglobuline polyclonale neutralisant les toxines de C. difficile et des méthodes d'identification de patients qui produisent l'immunoglobuline polyclonale neutralisant les toxines de C. difficile.

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