C - Chemistry – Metallurgy – 08 – L
Patent
C - Chemistry, Metallurgy
08
L
400/1000, 167/15
C08L 3/04 (2006.01) A61K 9/00 (2006.01) A61K 9/06 (2006.01) A61K 47/30 (2006.01) A61L 26/00 (2006.01) C08K 5/00 (2006.01) C08L 83/04 (2006.01) C08L 89/00 (2006.01) C08L 93/00 (2006.01)
Patent
CA 2013476
ABSTRACT The specification describes and claims a paste-like preparation comprising (A) a paste-like base comprising a polyorganosiloxane and a water-soluble polymeric material which are preferably present in a ratio by weight from 3:6 to 6:3 and (B) an active ingredient. The polyorganosiloxane is substantially linear and comprises predominantly R2SiO units and chain terminating units R'R2Si01/2 where each R represents a lower alkyl group, a halogenated alkyl group 9 an alkenyl group or an aryl group and each R' represents a group R or a hydroxyl group, and the polyorganosiloxane is a liquid or a gum at 25°C. The water-soluble polymeric material may provide from 10 to 90% by weight of the base and may be chosen from water-soluble polymers and copolymers of acrylic acid, methacrylic acid, acrylamide, cellulose derivatives and salts thereof, carboxymethylchitin, polyvinylpyrollidone, polyvinyl alcohol, starch derivatives, polyethylene oxide, gelatin, collagen and natural gums. The water-soluble polymeric material may be a particulate solid, the particles of which have a mean diameter of 2 to 100 micrometers. The preparation may comprise up to 70% by weight of a paste adjusting component chosen from fatty materials. The active ingredient may comprise for example a perfume, antiseptic or fertilizer or a drug, or quasi-drug, for example, a germicidal, antibiotic, anaesthetic, chemotherapeutic, vasodilator, expectorant, antianginal, hemostatic, gastrointestinal, antidiabetic, hormone or contraceptive agent. The preparation is capable of adhering to wet surfaces such as mucosa and of releasing the active ingredient whilst adhered to the surface.
Ninomiya Hiroshi
Urabe Yosuke
Dow Corning Kabushiki Kaisha
Gowling Lafleur Henderson Llp
Nippon Kayaku Kabushiki Kaisha
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