A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/102 (2006.01) A61K 39/39 (2006.01) G01N 33/569 (2006.01)
Patent
CA 2164701
Protection of ruminants against bacterial pneumonia caused by Pasteurella haemolytica has been achieved with a subunit vaccine. The vaccine contains two principle components; capsular polysaccharide of P. haemolytica and a synthetic adjuvant, muramyl dipeptide. This vaccine prevented bacterial infection of the lungs of vaccinated animals upon challenge with P. haemolytica. In contrast, animals that were not vaccinated or animals that were vaccinated with only capsular polysaccharide alone had severe lesions and high concentrations of P. haemolytica in the lungs.
La protection des ruminants contre la pneumonie bactérienne induite par la Pasteurella haemolytica est assurée au moyen d'un vaccin à sous-unités. Ledit vaccin contient deux composants principaux: un polysaccharide de P. haemolytica et un adjuvant synthétique, soit un dipeptide de muramyle. Ledit vaccin prévient l'infection bactérienne des poumons d'animaux vaccinés qui viendraient au contact de P. haemolytica. En revanche, les animaux n'ayant pas été vaccinés ou les animaux ayant été vaccinés avec seulement un polysaccharide capsulaire présentent des lésions graves et des concentrations élevées de P. haemolytica dans les poumons.
Brogden Kim A.
Chedid Louis
Borden Ladner Gervais Llp
The United States Of America As Represented By The Secretary Of Agricul Ture
Vacsyn S.a.
LandOfFree
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