C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/02 (2006.01) C12M 1/34 (2006.01) G01N 1/00 (2006.01) G01N 1/14 (2006.01) G01N 27/00 (2006.01) G01N 33/487 (2006.01)
Patent
CA 2203886
Apparatus for carrying out patch clamp technique utilized in studying the effect of certain materials on ion tranfer channels in biological tissue, and more particularly patch clamp apparatus utilizing an autosampler, such as those utilized with HPLC apparatus, to provide high throughput, is disclosed. The invention additionally includes novel microperfusion chamber assemblies capable of utilizing only small amounts of material to be tested and only small amounts of liquid carrier, thereby enabling many tests to be completed in a short period of time. The invention more broadly relates to a novel electrophysiology drug handling and application set up for screening of chemical substances while providing high throughput and requiring only low volume of solutions and samples to be tested. The invention also comprises several novel procedures for utilizing the apparatus of the invention.
Appareil permettant d'appliquer la méthode de patch-clamp employée dans l'étude de l'effet de certaines matières sur les canaux de tranfert ioniques dans le tissu biologique. L'invention concerne plus précisément un appareil de patch-clamp doté d'un autoéchantillonneur tel que ceux employés avec un appareil de chromatographie liquide à haute performance. L'invention comprend en outre de nouveaux assemblages de chambres de microperfusion n'exigeant que peu de substances d'essai et de petites quantités de véhicule liquide, ce qui permet d'effectuer un grand nombre d'essais en peu de temps. L'invention traite, plus généralement, d'un nouveau dispositif électrophysiologique d'administration et de maniement des médicaments destiné au criblage de substances chimiques, pouvant fournir un débit élevé et n'exigeant qu'un faible volume de solutions et peu d'échantillons d'essai. L'invention comprend également plusieurs nouvelles techniques d'utilisation de l'appareil.
Christophersen Palle
Olesen Soren-Peter
Neurosearch A/s
Perley-Robertson Hill & Mcdougall Llp
Sophion Bioscience A/s
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