Patch containing fentanyl for mucous membrane of oral cavity

Details Patch containing fentanyl for mucous membrane of oral cavity Patch containing fentanyl for mucous membrane of oral cavity

A - Human Necessities

61

K

A61K 31/4468 (2006.01) A61K 9/70 (2006.01) A61K 47/32 (2006.01) A61K 47/38 (2006.01) A61P 25/04 (2006.01)

Patent

CA 2493604

A phentanyl-containing adhesive patch for application to the oral-cavity mucosa which can rapidly increase the concentration of phentanyl drug in the blood, is effective in diminishing drug migration to the digestive tract, and is easy to handle and highly safe. The phentanyl-containing adhesive patch for application to the oral-cavity mucosa comprises: a drug layer comprising phentanyl or a salt thereof as a medicinal component, a methyl vinyl ether/maleic anhydride copolymer as a pressure-sensitive adhesive, and at least one substance selected among hydroxypropyl cellulose, hydroxypropyl methyl cellulose, and hydroxyethyl cellulose as a thickener; a support layer which is insoluble or sparingly soluble in water; and a substrate, the support layer and the substrate having been superposed in this order on one side of the drug layer.

L'invention concerne une mouche adhésive contenant du phentanyle destinée à être appliquée sur la muqueuse de la cavité orale. Cette mouche adhésive, qui permet d'augmenter rapidement le taux de phentanyle dans le sang et de réduire efficacement la migration des médicaments vers le tube digestif, est facile à manipuler et hautement fiable. Cette mouche adhésive comprend : une couche de médicament contenant du phentanyle ou un sel de ce dernier en tant que composant médicinal, un copolymère éther méthylvinylique/anhydride maléique en tant qu'adhésif autocollant et au moins une substance choisie dans le groupe constitué d'hydroxypropylcellulose, d'hydroxypropylméthylcellulose et d'hydroxyéthylcellulose en tant qu'épaississant ; une couche de support qui est insoluble ou peu soluble dans l'eau ; et un substrat ; la couche de support et le substrat ayant été superposés dans cet ordre sur un côté de la couche de médicament.

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